
ProFuse
Overview: ProFuse
The company is tackling the urgent need for effective treatments for muscle-wasting diseases. Utilizing its proprietary muscle growth technology, it aims to efficiently and accurately discover novel therapies which could benefit an estimated 45M patients in the US alone. According to the company, its platform is the only one capable of high-throughput screening of thousands of compounds, identifying promising candidates with high translational potential for muscle preservation and growth.
For the cultivated meat sector, Profuse offers cutting-edge products, including cell lines and differentiation media supplements. These innovations significantly reduce costs, enhance muscle growth, increase yield, and accelerate production cycles. ProFuse collaborates with leading companies to seamlessly integrate its products and expertise into their production and scale-up processes.
Founded in 2021, ProFuse is built on technology developed over six years of research at the Weizmann Institute of Science. Since its inception, the company has achieved significant milestones, including winning first place in the 2021 Israel Startup Competition and securing exclusive grants from the European Innovation Council and the Israel Innovation Authority.
Its R&D team is dedicated to skeletal muscle biology, strengthened by the expertise of Professors Eldad Tzahor (Weizmann Institute of Science, Israel) and Shulamit Levenberg (Technion, Israel), along with Dr. Ralph Laufer, a veteran in drug discovery, who sits on the company’s scientific advisory board.
The details here are based on information received from, and verified solely by, the company.
Co Investors
ProFuse Management Team
Tamar Eigler-Hirsh, PhD
Co-founder and CTO
Dr. Eigler-Hirsh has expertise in muscle development and regenerative biology and as well as processes of muscle stem cell differentiation, fusion, and maturation. Tamar’s postdoctoral research was focused on processes involved in the regulation of muscle progenitor cell differentiation and fusion. She characterized the molecular signaling pathway which is the basis of the ProFuse technology. Dr. Eigler-Hirsh received her BA from Brandeis University (Waltham, Massachusetts), then a PhD in biomedical sciences and translational medicine under the mentorship of Shlomo Melmed at Cedars-Sinai Medical Center, Los Angeles, California. Her doctoral work in molecular endocrinology focused on somatostatin receptor regulation of growth hormone synthesis in pituitary tumors. She then completed postdoctoral training under the mentorship of Prof. Tzahor at the Weizmann Institute of Science where she was the recipient of the Dean of Faculty postdoctoral fellowship.
Guy Nevo Michrowski
Co-founder and CEO
A seasoned entrepreneur with over 20 years of extensive experience in management, fund raising, marketing, business development, and sales, Guy has expertise in the fields of technology, automotive, energy storage, internet of things (IoT), imaging, smartphone developments, and wireless power. Guy has a proven record of growing startups from inception to exit as well as management positions in global companies. A great supporter of sustainability, a former chef, and vegan for over 10 years, Guy brings a passion for promoting new technologies and ideas to the food industry. Guy earned his BSc in international business management, summa cum laude, from University of Surrey, UK, and is a graduate of modules in the executive program of Northwestern University - Kellogg School of Management.
Prof. Eldad Tzahor, PhD
Scientific Founder
Tzahor serves as the head of the molecular cell biology department at the Weizmann Institute of Science; his laboratory focuses on the development of novel therapeutic approaches by understanding the signaling mechanisms and cellular circuits that regulate muscle biology. Dr. Tzahor has published around 70 papers and numerous patents. He is the recipient of several prestigious grants and awards, including two European Research Council (ERC) grants, Foundation LeDucq, Horizon 2020 Regenerative Medicine, and the Levinson Prize in Biology. In recent years Prof. Tzahor has been involved in commercial and business development efforts for launching cardiac regeneration-targeted novel therapies.
Dr. Ori Avinoam, PhD
Scientific Founder
Dr. Avinoam is an expert in processes of cell-to-cell fusion and membrane remodeling, as well as multi-modal imaging techniques. A primary research focus of Dr. Avinoam’s laboratory is understanding the molecular mechanisms which regulate muscle cell fusion. He earned a BSc in molecular biochemistry from the Technion – Israeli Institute of Technology and his PhD in biology from the Technion in 2012 studying the mechanism by which membrane proteins enable cell-to-cell fusion. A postdoctoral fellowship followed at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany where he worked to develop the means to visualize dynamic changes in membrane architecture. He joined the faculty of the Weizmann Institute of Science in 2017. Having received fellowships for academic excellence in 2008, 2009, and 2011, Dr. Avinoam received an EIPOD interdisciplinary postdoctoral fellowship in 2012. He is the recipient of prestigious grants including those from the Israel Science Foundation (ISF) and the European Research Council (ERC).
At a Glance: ProFuse
ProFuse: Leading the Way in Skeletal Muscle Growth
ProFuse is the global leader in skeletal muscle growth, developing innovative drugs for muscle preservation and regeneration, and offering products for enhanced cultivated muscle meat production.
Addressing Essential Health Needs
Skeletal muscle mass is crucial for health and longevity, yet it diminishes due to weight loss (e.g., from GLP-1 drugs) and aging (sarcopenia). ProFuse utilizes the only high-throughput drug discovery platform to develop therapies for muscle preservation and growth.
Innovations for the Cultivated Meat Industry
For the cultivated meat industry, Profuse provides advanced muscle cell lines and muscle differentiation media supplements to enhance muscle growth, increase yield, accelerate production cycles, and reduce costs. Its products, PROFUSE-S1 (differentiation media supplement) and PROFUSE-S8 (bovine muscle cell line), are already available for purchase.
Leadership and Expertise
ProFuse is led by seasoned entrepreneur Guy Nevo Michrowski, CEO and co-founder, and Dr. Tamar Eigler Hirsh, CTO and co-founder. The company’s groundbreaking technology was developed over six years of research at the Weizmann Institute of Science, led by Professor Eldad Tzahor. Its team is uniquely focused on skeletal muscle biology, comprising 15 experts including six PhDs and seven MSc holders. ProFuse won the 2021 Israel Startup Competition and received exclusive grants from the EU and the Israel Innovation Authority.
Information sourced from www.profuse-tech.com, verified solely by the company.